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首页-抗体和重组蛋白-Biosimilar Antibody-[Ipilimumab
[Ipilimumab

Chemical Structure : [Ipilimumab

CAS No.: 477202-00-9

[Ipilimumab (Anti-human CD152/CTLA4 mAb, human IgG1-Kappa)

货号: PC-Ab1018Not For Human Use, Lab Use Only.

Ipilimumab is a fully human IgG1κ antibody that binds to CTLA-4 (cytotoxic T lymphocyte-associated antigen 4), a molecule on T-cells that is indicated for unresectable or metastatic melanoma. The absence or presence of CTLA-4 can augment or suppress the immune system’s T-cell response in fighting disease. Ipilimumab is designed to block the activity of CTLA-4, thereby sustaining an active immune response in its attack on cancer cells. The proposed mechanism of action is indirect, and may be thro

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ipilimumab is a fully human IgG1κ antibody that binds to CTLA-4 (cytotoxic T lymphocyte-associated antigen 4), a molecule on T-cells that is indicated for unresectable or metastatic melanoma. The absence or presence of CTLA-4 can augment or suppress the immune system’s T-cell response in fighting disease. Ipilimumab is designed to block the activity of CTLA-4, thereby sustaining an active immune response in its attack on cancer cells. The proposed mechanism of action is indirect, and may be through T-cell – mediated anti-tumor immune responses.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

Ipilimumab; Yervoy; MDX-010; BMS-73401; cytotoxic T-lymphocyte-associated protein 4;CTLA-4 protein; CD152; 477202-00-9; cytotoxic T-lymphocyte antigen 4

参考文献

1. 1, Wolchok JD, et al. Lancet Oncol. 2010 Feb;11(2):155-64. 2, Bashey A, et al. Blood. 2009 Feb 12;113(7):1581-8.  3, Yang JC, et al. J Immunother. 2007 Nov-Dec;30(8):825-30. 4, O'Day SJ, et al. Cancer. 2007 Dec 15;110(12):2614-27.

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